Pharmaceutical Chemistry – II

Multiple Choice Questions 6 Pages

University of Mumbai

Bachelor of Pharmacy

MPS

Contributed by

Mahmood Prasoon Sarna

CBCS – SEM VII - Pharmaceutical Chemistry – II - Practice MCQs
Note: The right answer is denoted by (A) in front of the option
1. Which of the following is an Angiotensin II receptor blocker?
a) Aliskiren
b) Ramipril
c) Valsartan (A)
d) Captopril

2. Which of the following anti-anginal drugs show their action by releasing Nitric Oxide?
a) Bepridil
b) Amyl Nitrate (A)
c) Diltiazem
d) Verapamil

3. __________is DHFR inhibitor
a) Methotrexate (A)
b) 5-Flurouracil
c) Streptozotocin
d) Melphalan

4. Which of the following antiarrhythmic drug has a pyridine ring present in the structure?
a) Lidocaine
b) Disopyramide (A)
c) Procainamide
d) Mexiletine

5. In classification of Calcium channel blockers, Verapamil belongs to which chemical class?
a) Phenylalkylamines (A)
b) 1,4 – Dihydropyridine
c) Benzothiazepine
d) Benzothiadiazine
Page 1
6. Which of the following antiviral drug belongs to Protease inhibitor
a) Lamivudine
b) Nevirapine
c) 5-Fluorouracil
d) Saquinavir (A)

7. In the classification of Sympatholytics, Carvedilol belongs to which chemical class?
a) α - 1 blocker
b) β – 1 blocker
c) Non-selective β blocker
d) Mixed α – β blocker (A)

8. For the following structure, choose the right IUPAC nomenclature

a) p-amino-N-[2-(diethylamino)ethyl] benzamide (A)
b) p-amino-N-[3-(dimethylamino)ethyl] benzamide
c) p-amino-N-[2-(dimethylamino)ethyl] benzamide
d) p-amino-N-[3-(diethylamino)ethyl] benzamide

9. In the classification of diuretics, Furosemide belongs to which class?
a) Thiazide diuretics
b) Osmotic diuretics
c) Loop diuretics (A)
d) Potassium sparing

Page 2
10. Which of the following drug is synthesized using phthalic anhydride as a starting material.
a) Hydralazine (A)
b) Prazosin
c) Acetazolamide
d) Dipyridamole

11. In the classification of hypoglycemics, Pioglitazone belongs to which chemical class?
a) Sulfonylureas
b) GLP -1 agonists
c) Biguanides
d) Thiazolidinediones (A)

12. In the classification of anti-arrhythmic drugs, Quinidine belongs to which class?
a) Class IB
b) Class IC
c) Class IA (A)
d) Class III

13. Which of the following is anticancer prodrug?
a) Mechlorethamine
b) Cyclophosphamide (A)
c) Chlorambucil
d) Busulfan

14. Which of the following Thiazide like diuretic drug is a phthalimidine derivative
a) Metalozone
b) Chlorthiazide
c) Chlorthalidone (A)
d) Indapamide

Page 3
15. Identify which of the following anti-diabetic drug belongs to 1
st
generation of
sulfonyl ureas?
a) Metformin
b) Acetohexamide (A)
c) Glyburide
d) Pioglitazone

16. Identify the name of following drug.

a) Cisplatin
b) Oxaliplatin (A)
c) Vinblastine
d) Bleomycine

17. What does the enzyme HDAC stand for?
a) Histone Deacetylase (A)
b) Histone Demethylase
c) Histidine Deacetylase
d) Histidine Demethylase

18. Suggest the name of intermediate involved in mechanism when a nitrogen mustard
like Melphalan alkylates the N7 position of Guanine?
a) Carbocation
b) Carboanion
c) Aziridinium ion (A)
d) Free radical

Page 4
19. Which of the following Angiotensin II blocker has a benzimidazole ring present?
a) Losartan
b) Valsartan
c) Candesartan (A)
d) Olmesartan

20. Which of the following is transition state inhibitor?
a) Zanamivir (A)
b) Nevirapine
c) Acyclovir
d) Efavirenz

21. Which of the following is cholesterol absorption inhibitor?
a) Atorvastatin
b) Ezetimib (A)
c) Gemfibrozil
d) Lovastatin

22. Which of the following antihistaminic drug belongs to Propylamine chemical class?
a) Pheniramine (A)
b) Promethazine
c) Chlorcyclizine
d) Doxylamine

23. Which of the following anesthetic drug belongs to chemical class of amine ester?
a) Lidocaine
b) Mepivacaine
c) Bupivacaine
d) Benzocaine (A)

Page 5
24. Which of the following is mitotic inhibitor?
a) Imatinib
b) Dasatinib
c) Lapatinib
d) Vincristine (A)

25. Which of the following group from ACE inhibitor binds to Zn
+2

a) H
2
O
b) SH-CH
2
- (A)
c) –COOH
d) –CHO
Page 6